منابع مشابه
Bile salts and calcium absorption.
1. The study of the effect of bile salts on enhancing calcium absorption in the rachitic chick has been extended to bile salts not present in chick bile, e.g. glycine conjugates and bile alcohol sulphates. 2. Bile and bile salts cause an increase in calcium absorption from sparingly soluble calcium hydrogen phosphate when compared with a suspension of calcium hydrogen phosphate in saline. 3. If...
متن کاملBile salts and fat absorption.
There has been a recent resurgence of interest in bile salt metabolism. Normally the body contains about 3 g. of bile salts. These comprise conjugates of cholic acid and chenodesoxycholic acid. The free acids are derived from the oxidation of cholesterol in the liver and once formed are conjugated with either taurine or glycine, after which they are secreted into the bile and so enter the small...
متن کاملAbsorption-Enhancing Effects of Bile Salts.
Bile salts are ionic amphiphilic compounds with a steroid skeleton. Among the most important physiological properties of bile salts are lipid transport by solubilization and transport of some drugs through hydrophobic barriers. Bile salts have been extensively studied to enhance transepithelial permeability for different marker molecules and drugs. They readily agglomerate at concentrations abo...
متن کاملNasal absorption of insulin: enhancement by hydrophobic bile salts.
We demonstrate that therapeutically useful amounts of insulin are absorbed by the nasal mucosa of human beings when administered as a nasal spray with the common bile salts. By employing a series of bile salts with subtle differences in the number, position, and orientation of their nuclear hydroxyl functions and alterations in side chain conjugation, we show that adjuvant potency for nasal ins...
متن کاملEnhancing Effect of Bile Salts on Gastrointestinal Absorption of Insulin
Purpose: To investigate the effect of co-administration of two absorption enhancing bile salts, sodium glycocholate (NaGc) and sodium salicylate (NaSal), on insulin absorption via intestinal targeted delivery system. Methods: Insulin (10 IU/kg), associated with and without absorption enhancers (5 % enhancer solution of NaGc or NaSal), was administered to the duodenum, jejunum, and ileum part of...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1966
ISSN: 0006-2936
DOI: 10.1042/bj1000652